Effects of Selected Anionic β-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats
In vivo pharmacokinetics parameters of insulin glargine with or without SBE7-β-CyD (200 mM). (1) Time required to reach the maximum serum insulin glargine level. (2) Maximum serum insulin glargine level. (3) Area under the serum insulin glargine level-time curve up to 12 h after-administration. (4) Mean residence time in plasma. Each value represents the mean ± S.E.M. of 4–6 experiments. *, compared to insulin glargine.
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