Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine

Figure 4

(a) Pharmacokinetic profile of ¹²⁵I-labeled gWiz Luc plasmid DNA with no delivery vector with an initial dose of 70 μg of the plasmid containing approximately 1 μCi of radiation. (b) Comparison of the organ biodistribution of ¹²⁵I-labeled plasmid containing the luciferase gene complexed with no vector (black), linear PEI (light grey), and N-ethylated linear PEI (dark grey) at 15 minutes.

(a)

(b)