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Journal of Drug Delivery
Volume 2011, Article ID 326497, 12 pages
http://dx.doi.org/10.1155/2011/326497
Review Article

Liposomes for Use in Gene Delivery

Laboratory for Gene Therapy and Cellular Engineering, Department of Chemical and Biomolecular Engineering, Tulane University, 6823 St. Charles Avenue, 300 Lindy Boggs Center, New Orleans, LA 70118, USA

Received 30 June 2010; Accepted 29 October 2010

Academic Editor: Seyed Moein Moghimi

Copyright © 2011 Daniel A. Balazs and WT. Godbey. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid composition. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.