The Use of Radioactive Marker as a Tool to Evaluate the Drug Release in Plasma and Particle Biodistribution of Block Copolymer Nanoparticles

Figure 3

Plasma ³[H] clearance of  ³[H] CHE-labelled PS nanoparticles or plasma clearance of CHE-labelled Propac 7/POPC/PS 1 : 1 : 2 nanoparticles. The ³[H] CHE plasma profile is shown for the PEG-3K PS nanoparticles and both the ³[H] CHE-labelled and Propac 7 profiles are shown for the Propac 7/POPCPS nanoparticles. Each data point represents the mean (± standard deviation) of three mice. Clearance of Propac 7/POPC/2.5K PEG-3K PS is significantly faster than drug-free nanoparticles (𝑃<0.05 at each time points).