The Use of Radioactive Marker as a Tool to Evaluate the Drug Release in Plasma and Particle Biodistribution of Block Copolymer Nanoparticles

Figure 5

Plasma clearance and tissue accumulation of  ³[H] CHE-labelled Propac 7/POPC/PS nanoparticles. Plasma ³[H] profile and ³[H] tissue accumulation from HCT116 tumor-bearing mice injected with ³[H] CHE-labelled Propac 7/POPC/PS 1 : 1 : 2 (6 mg/kg Propac 7). Only ³[H] was measured. Data points are the average of two mice. (a) plasma, (b) lung, (c) kidney, (d) spleen, (e) tumor, and (f) liver.

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