Modeling Drug-Carrier Interaction in the Drug Release from Nanocarriers
Figure 2
Dependence of release kinetics on model parameters. (a) Free energy difference (, day−1). (b) Diffusion/convection rate constant ( = −2 × 10−21 J) = 0.001 day−1). (c) Disassociation rate constant ( = −2 × 10−21 J, day−1). (d) The model resembles the four categories of drug release profiles. , , used in (4): 4 × 10−21 J, 0.18, 0.002 day−1 for category I; −4 × 10−21 J, 0.18, 0.001 day−1 for category II; 1 × 10−21 J, 0.24, 0.015 day−1 for category III; and −5 × 10−21 J, 0.36, and 0.013 day−1 for category IV). In (a)–(c), solid and dashed lines represent the model prediction using (4) and (6), respectively.