Modeling the Release Kinetics of Poorly Water-Soluble Drug Molecules from Liposomal Nanocarriers

Figure 5

Fraction of drug molecules contained in donor liposomes (𝑀_𝑑(𝑡)/𝑀; upper set of curves) and acceptor liposomes (𝑀_𝑎(𝑡)/𝑀; lower set of curves) as function of the scaled time 𝐾𝑡. The curves represent numerical solutions of (2) and (4) with (22), derived for 𝑘=0 and 𝑚=100 with the initial conditions 𝑑_𝑗(0)=0 for 𝑗≠𝑙, 𝑑_𝑙(0)=100, 𝑎_𝑗(0)=0 for 𝑗>0, 𝑎₀(0)=100. Different curves correspond to 𝑙=2 (a), 𝑙=10 (b), 𝑙=50 (c), 𝑙=90 (d), and 𝑙=98 (e).