Modeling the Release Kinetics of Poorly Water-Soluble Drug Molecules from Liposomal Nanocarriers

Figure 6

Fractions of drug molecules in inner and outer leaflets of donor and acceptor liposomes. The quantities 𝑀^𝑂_𝑑(𝑡), 𝑀^𝐼_𝑑(𝑡), 𝑀^𝑂_𝑎(𝑡), and 𝑀^𝐼_𝑎(𝑡) are plotted according to (26) for 𝐺/𝐾=1/10 and 𝑁_𝑎/𝑁=𝑁_𝑑/𝑁=0.5. The broken lines show the biexponential behaviors of the sums 𝑀_𝑑=𝑀^𝑂_𝑑+𝑀^𝐼_𝑑 and 𝑀_𝑎=𝑀^𝑂_𝑎+𝑀^𝐼_𝑎. The time is plotted in units of the inverse rate constant 𝐾. Note also 𝜔₁=1.11𝐾 and 𝜔₂=0.09𝐾 are the effective rate constants for the decay.