Journal of Drug Delivery / 2011 / Article / Tab 1

Review Article

Prophylaxis of Postoperative Nausea and Vomiting in Adolescent Patients: A Review with Emphasis on Combination of Fixed-Dose Ondansetron and Transdermal Scopolamine

Table 1

Prophylactic antiemetic agents supported by medical evidence for use in pediatric and adult patients. The high end of the pediatric range often overlaps or is equivalent to the recommended adult dose [20].

DrugType of drugPediatric doseAdult doseComment

DexamethasoneCorticosteroid150 μg/kg up to 5 mg4-5 mgAdult and pediatric doses overlap
DimenhydrinateAntihistamine0.5 mg/kg up to 25 mg1 mg/kg
Dolasetron5-HT3 antagonist350 μg/kg up to 12.5 mg12.5 mgAdult and pediatric doses overlap
DroperidolAntidopaminergic drug10–15 μg/kg up to 1.25 mg0.625–1.25 mgBlack box warnings, high risk of sedation
Granisetron5-HT3 antagonist40 μg/kg up to 0.6 mg0.35–1.5 mgAdult and pediatric doses overlap
Ondansetron5-HT3 antagonist50–100 μg/kg up to 4 mg4 mgAdult and pediatric doses overlap
PerphenazinePhenothiazine (antipsychotic)70 μg/kg up to 5 mgNAOnly oral formulation is available in USA
Tropisetron5-HT3 antagonist0.1 mg/kg up to 2 mg2 mgAdult and pediatric doses overlap

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