Safety Evaluation of EXPAREL (DepoFoam Bupivacaine) Administered by Repeated Subcutaneous Injection in Rabbits and Dogs: Species Comparison
Figure 1
Injection Site Findings in Rabbits on Day 26. (a): Saline Control. H&E 4x, (b): Bupivacaine HCl Solution, 9 mg/kg. H&E 4x, (c): DepoFoam Bupivacaine 30 mg/kg H&E 20x. Annotations are as follows: Black arrows: vacuolated macrophages, White arrows: neovascularization, black asterisks: inflammation (chronic-active to chronic), white asterisks: mineralization.
