Safety Evaluation of EXPAREL (DepoFoam Bupivacaine) Administered by Repeated Subcutaneous Injection in Rabbits and Dogs: Species Comparison
Figure 2
Injection site findings in dogs on day 54. (a): Saline control. H&E 2x, (b): bupivacaine HCl solution, 9 mg/kg. H&E 2x, (c): DepoFoam Bupivacaine 30 mg/kg H&E 4x. Annotations are as follows: black arrows: vacuolated macrophages, white arrows: neovascularization, black asterisks: inflammation (chronic-active to chronic), white asterisks: mineralization
