Research Article
Safety Evaluation of EXPAREL (DepoFoam Bupivacaine) Administered by Repeated Subcutaneous Injection in Rabbits and Dogs: Species Comparison
Table 2
Accumulation ratios for EXPAREL and bupivacaine HCl solution (Day 25 versus Day 1) (mean ± SD; N = 3/sex/group).
(a) Rabbit |
| Treatment | Bupivacaine (mg/kg/dose) | Accumulation ratio (Day 25 versus Day 1) | (nghr/mL) | C
max(ng/mL) | t 1/2(hr) | t
max(hr) |
| Bupivacaine HCl | 9 | 0.88 | 1.02 | 1.17 | 1.07 |
| EXPAREL | 9 | 0.94 | 2.30 | 0.35 | 0.41 | 18 | 1.55 | 2.36 | 0.36 | 1.40 | 30 | 2.14 | 3.09 | 1.42 | 0.29 |
|
|
(b) Dog |
| Treatment | Bupivacaine (mg/kg/dose) | Accumulation ratio (Day 25 versus Day 1) | (nghr/mL) | C
max(ng/mL) | t 1/2(hr) | t
max(hr) |
| Bupivacaine HCl | 9 | 0.94 | 1.40 | 0.60 | 1.0 |
| EXPAREL | 9 | 1.90 | 2.46 | 0.61 | 1.0 | 18 | 1.90 | 2.34 | 0.25 | 1.5 | 30 | 1.71 | 1.44 | 1.38 | 0.26 |
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