The Impact of Dosing Interval in a Novel Tandem Oral Dosing Strategy: Enhancing the Exposure of Low Solubility Drug Candidates in a Preclinical Setting

Table 1

Basic PK and physicochemical parameters of compound 1.

Parameters	Compound 1
𝐾𝑎 (−1/hr)	0.8
CL (mL/min/kg)	22
𝑉dss (L/kg)	6.0
𝑇1/2 (Hrs)	6.9
MRT Oral (3 mg/kg)/IV (1 mg/kg)	6.1/4.8 (hrs)
Oral BA (3 mg/kg)	60%
Aqueous solubility (pH 6.5)	10 μM
Solubility in FASSIF	15 μM
pKa (between pH 2 and 10)	None
Log 𝐷 (pH 7.4)	3.0