The Impact of Dosing Interval in a Novel Tandem Oral Dosing Strategy: Enhancing the Exposure of Low Solubility Drug Candidates in a Preclinical Setting

Table 4

Tandem dose scheme AUC comparison (μM*hr).

Dose (mg/Kg)/Interval (hrs)	1 hr	1.5 hr	2.5 hr
50 (mg/Kg) X3/AUC/Dose	85±41	159±69	147±31
100 (mg/Kg) X3	192±58	289±55	310±14
200 (mg/Kg) X3	210±26	330±90	521±47