A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect

Table 1

Characteristics and shelf stability of liposomes mainly composed of either natural EPC or HEPC alone.

Liposome composition	[Lipid] (mM)	Drug/PL (mole%)	[Paclitaxel] (mg/mL)^a	Mean particle size (nm)	I.E.^b (%)	Remaining content^c (%)
						14 days	30 days
EPC/Chol/MPEG	20	3	0.45	142.9	88.4	89.3	77.9
(20/8/1)	20	7	0.52	174.1	42.1	67.8	35.4
HEPC/Chol/MPEG; (20/8/1)	20	3	0.32	93.2	68.1	76.7	63.6

aConcentration of paclitaxel at day 0.
bIncorporation efficiency = paclitaxel incorporated in liposomes/paclitaxel added.
cRemaining content = [paclitaxel] at day N/[paclitaxel] at day 0.