A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect

Table 3

Effects of increasing paclitaxel to lipid molar ratio on physical properties of liposomes. Liposome formulation is composed of PCs, cholesterol, and MPEG at the optimal molar ratio (EPC/HEPC/Chol/MPEG = 15/5/2/1).

PC (mM)	Drug/PL^a (mole%)	[Paclitaxel] (mg/mL)	Mean particle size (nm)	I.E. (%)
20	7	1.0	114.3	84.5
40	7	2.0	115.8	82.4
20	10	1.3	116.2	78.8
20	15	2.1	125.4	81.0
20	20	2.9	134.9	85.1
20	25	2.3	146.3	54.6

aPL represents total phospholipids including EPC, HEPC and MPEG.