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Journal of Drug Delivery
Volume 2011 (2011), Article ID 727241, 11 pages
http://dx.doi.org/10.1155/2011/727241
Review Article

Targeted Liposomal Drug Delivery to Monocytes and Macrophages

1School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland
2Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland

Received 30 July 2010; Accepted 27 September 2010

Academic Editor: Juan M. Irache

Copyright © 2011 Ciara Kelly et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

As the role of monocytes and macrophages in a range of diseases is better understood, strategies to target these cell types are of growing importance both scientifically and therapeutically. As particulate carriers, liposomes naturally target cells of the mononuclear phagocytic system (MPS), particularly macrophages. Loading drugs into liposomes can therefore offer an efficient means of drug targeting to MPS cells. Physicochemical properties including size, charge and lipid composition can have a very significant effect on the efficiency with which liposomes target MPS cells. MPS cells express a range of receptors including scavenger receptors, integrins, mannose receptors and Fc-receptors that can be targeted by the addition of ligands to liposome surfaces. These ligands include peptides, antibodies and lectins and have the advantages of increasing target specificity and avoiding the need for cationic lipids to trigger intracellular delivery. The goal for targeting monocytes/macrophages using liposomes includes not only drug delivery but also potentially a role in cell ablation and cell activation for the treatment of conditions including cancer, atherosclerosis, HIV, and chronic inflammation.