IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models

Figure 1

Diagram of the IT-141 formulation. ITP-101 consists of poly(ethylene glycol)-b-poly(aspartic acid)-b-poly(D-leucine-co-tyrosine), where the hydrophobic amino acids provide a core region into which a hydrophobic drug can reside, and the amphiphilic PEG block forms a protective corona around the micelle. Addition of SN-38 (shown in red) to ITP-101 (see Section 2) forms an SN-38-loaded micelle, termed IT-141.