IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models
Figure 3
Antitumor efficacy of IT-141 in colorectal cancer xenograft models. (a) HT-29 tumor-bearing mice (eight mice per group) were injected intravenously with ITP-101 alone (300 mg/kg), IT-141 (30 mg/kg), or irinotecan (60 mg/kg) on a Q4D × 3 schedule. (b) HT-29 tumor-bearing mice (seven mice per group) were injected with 1, 5, 10, 15, 30, or 45 mg/kg of IT-141 along with a saline control group. (c) HCT-116 tumor-bearing mice (six mice per group) were injected with 5, 15, or 30 mg/kg of IT-141 along with saline and ITP-101 control. Asterisks denote that treatment group is statistically different from control group (). Arrows indicate days of injection (days 0, 4, and 8). Data are presented as mean tumor volume ± standard error.
