IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models

Table 1

IC50 values (𝜇M) of IT-141 compared to free SN-38 and irinotecan in cancer cell lines. Data are presented as mean ± standard deviation.

	Cell line	IT-141 (𝜇M)	Free SN-38 (𝜇M)	Irinotecan (𝜇M)
Colon	HT-29	0.0374±.001	0.0452±.002	24.6±6.4
	HCT-116	0.165±.021	0.133±.037	16.3±1.3
Prostate	PC-3	>5.0	>5.0	>100
	LNCaP	0.081±0.006	0.083±0.008	10.7±2.2
Osteosarcoma	MG-63	0.080±0.004	0.076±0.002	7.2±0.9
Pancreatic	BxPC-3	0.072±0.004	0.072±0.002	6.5±1.3
Breast	MDA-MB-453	0.679±0.006	0.661±0.038	>100
	MDA-MB-231	>1.0	>1.0	66.3±6.0
	MCF-7	0.717±0.141	0.529±0.017	86.0±4.6
	BT-474	>3.0	>3.0	>200
Lung	A549	0.091±0.002	0.099±0.001	7.7±1.0