IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models

Table 2

Plasma and tumor pharmacokinetics of IT-141 compared to irinotecan. Plasma AUC = 𝜇g*h/mL, tumor AUC = 𝜇g*h/g.

Drug	AUC	Half-life (h)	𝐶max (𝜇g/mL)
IT-141 (plasma)	34.6	8.5	209.5
Irinotecan (plasma)	2.5	1.6	1.0
IT-141 (tumor)	16.4	3.9	9.4
Irinotecan (tumor)	1.9	17.5	0.2