Optimization of Liposomal Lipid Composition for a New, Reactive Sulfur Donor, and In Vivo Efficacy Studies on Mice to Antagonize Cyanide Intoxication

Table 3

Encapsulation efficiencies for DTO in various liposome compositions with and without DOTAP. DTO concentration was 2.0 mM. Total lipid concentration was 10.0 mg/mL.

Liposomal composition (mol%)				Encapsulation efficiency (%) with various lipid components
Lipid	Chol	PEG-PE-2000	DOTAP	POPC	DOPC	LEC
82.71	9.19	5.1	3.0	78.4 ± 2.3	81.7 ± 3.1	64.3 ± 3.0
85.41	9.49	5.1	—	60.7 ± 3.0	63.8 ± 1.2	61.6 ± 1.5