Journal of Drug Delivery / 2011 / Article / Tab 4

Research Article

Optimization of Liposomal Lipid Composition for a New, Reactive Sulfur Donor, and In Vivo Efficacy Studies on Mice to Antagonize Cyanide Intoxication

Table 4

Prophylactic protection by various cyanide antidotal combinations. APR denotes antidotal potency ratio, which can be calculated as the ratio of the average LD50 of CN with and without antagonists.

Exp no.TreatmentLD50 (mg/kg; mean; range)APR

1Control7.8 (4.6–13.1)1
2(SL-DTO) (iv) + CN (sc)17.3 (9.8–30.7)2.2
3(SL-DTO-TS) (iv) + CN (sc)38.0 (21.5–67.3)4.8
4(SL-DTO-TS) (iv) + SN (ip) + CN (sc)52.7 (29.7–93.2)6.7
5(SL-DTO-Rh) (iv) + CN (sc)30.7 (14.6–64.0)3.9
6(SL-DTO-TS-Rh) (iv) + CN (sc)38.0 (22.6–64.2)4.9
7(SL-DTO-TS-Rh) (iv)+ SN (ip) + CN (sc)120.0 (68.2–213.0)15.3

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