Optimization of Liposomal Lipid Composition for a New, Reactive Sulfur Donor, and In Vivo Efficacy Studies on Mice to Antagonize Cyanide Intoxication

Table 4

Prophylactic protection by various cyanide antidotal combinations. APR denotes antidotal potency ratio, which can be calculated as the ratio of the average LD₅₀ of CN with and without antagonists.

Exp no.	Treatment	LD50 (mg/kg; mean; range)	APR
1	Control	7.8 (4.6–13.1)	1
2	(SL-DTO) (iv) + CN (sc)	17.3 (9.8–30.7)	2.2
3	(SL-DTO-TS) (iv) + CN (sc)	38.0 (21.5–67.3)	4.8
4	(SL-DTO-TS) (iv) + SN (ip) + CN (sc)	52.7 (29.7–93.2)	6.7
5	(SL-DTO-Rh) (iv) + CN (sc)	30.7 (14.6–64.0)	3.9
6	(SL-DTO-TS-Rh) (iv) + CN (sc)	38.0 (22.6–64.2)	4.9
7	(SL-DTO-TS-Rh) (iv)+ SN (ip) + CN (sc)	120.0 (68.2–213.0)	15.3