Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications

Table 1

PEG therapeutic systems with in the market or clinical development.

Product name	Description	Clinical use	Route of admin.	Stage
PEG-protein conjugates
Oncaspar	PEG-asparaginase	Acute lymphocytic leukaemia	iv/im	Market
Adagen	PEG-adenosine deaminase	Severe combined immune deficiency syndrome	im	Market
Somavert	PEG-HGH antagonist	Acromegaly	sc	Market
PEGIntron	PEG-Interferon alpha 2b Hepatitis C	Hepatitis C	sc	Market
NeulastaTM	PEG-rhGCSF Chemotherapy	Chemotherapy-induced neutropenia	sc	Market
Pegasys	PEG-interferon alpha 2a hepatitis C	Hepatitis C	sc	Market
CimziaTM	PEG-anti-TNF Fab	Rheumatoid arthritis, Crohn’s disease	sc	Market
Mircera	PEG-EPO	Anaemia associated with chronic kidney disease	iv/sc	Market
Puricase	PEG-uricase	Gout	iv	Market
Macugen	PEG-aptamer	Age-related macular degeneration	Intraviteal	Market
PEG-drug conjugates
NKTR-102	PEG-irinotecan	Cancer-metastatic breast	iv	Phase II
PEG-SN38	Multiarm PEG-camptothecan derivative	Cancer-various	iv	Phase II
NKTR-118	PEG-naloxone	Opioid-induced constipation	Oral	Phase II