The Treatment of Breast Cancer Using Liposome Technology

Table 1

Recently reported targeted liposome-based chemotherapeutics to treat breast cancer. PE38KDEL from reference [26] is a 38 kDa mutant form of pseudomonas exotoxin A (PE), and the peptide sequence from reference [27] is DMPGTVLP.

Cell-surface target	Targeting ligand	Encapsulated cargo	Reference
HER2	Anti-HER2 Fab’	PE38KDEL	[26]
Transferrin receptor	Antitransferrin receptor antibody	HER-2 siRNA	[28]
MCF-7 cell specific	Peptide	PRDM14 siRNA	[27]
Estrogen receptor	17β-estradiol	Anticancer gene	[29]
Estrogen receptor	Estrone	Doxorubicin	[30]
Lectins	Selectin ligand (SiaLe^X)	Merphalan	[31]