Cyclodextrin-Containing Polymers: Versatile Platforms of Drug Delivery Materials
Figure 6
Effect of imidazole incorporation within CDP upon gene delivery efficiency and intracellular siRNA release. (a) Incorporation of an imidazole derivative within CDP (CDPim) leads to a significant increase in transgene (luciferase) expression levels in transfected HeLa and BHK-21 cells (from [33]). (b) Imidazole incorporation (CDPimid) yields a significant (~4x) increase in the fraction of intracellular siRNA that is released from the polymer and able to migrate through an agarose gel when electrophoresed (from [34]).
