Cyclodextrin-Containing Polymers: Versatile Platforms of Drug Delivery Materials

Table 1

Key nanoparticle characteristics and their effect on in vivo functionality.

Nanoparticle characteristics	Function
Diameter between 10 and 100 nm	Control over pharmacokinetics and biodistribution
Surface properties (charge, hydrophilicity)	Solubility, protection from aggregation, and interaction with cells and proteins
Core properties	Protection of payload from chemical and enzymatic inactivation, control of release kinetics
Linker chemistry	Protection of drug from chemical or enzymatic inactivation, control of release kinetics
Targeting ligands	Control of cell surface binding and intracellular uptake