Cyclodextrin-Containing Polymers: Versatile Platforms of Drug Delivery Materials

Table 2

Linkers and drugs evaluated with the CDP nanoparticle system. The cleavage position is indicated with an arrow.

Drug	Linker Aqueous solubility	Polymer Mw Drug loading Particle size
20-S-Camptothecin (CRLX-101, formerly IT-101)		35–85 kDa 6–12% w/w 20–40 nm
Tubulysin A		67 kDa 12–16% w/w 100–130 nm
α-Methylprednisolone		137 kDa 12.4% w/w 27 nm