A New Application of Lipid Nanoemulsions as Coating Agent, Providing Zero-Order Hydrophilic Drug Release from Tablets

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left"></td><td align="center">Tablets (A)</td><td align="center">Tablets (B)</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Weight (mg)</td><td align="center"><span style="width: 49.037498px;"><svg height="12.05" id="M7" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 49.037498 12.05" width="49.037498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="21.530167" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="32.870388" y="0">2</tspan>
</text>
</g>
</g>
</svg></span></td><td align="center"><span style="width: 49.037498px;"><svg height="12.05" id="M8" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 49.037498 12.05" width="49.037498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="21.530167" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="32.870388" y="0">3</tspan>
</text>
</g>
</g>
</svg></span></td></tr><tr><td align="left">Hardness (N)</td><td align="center"><span style="width: 64.662498px;"><svg height="12.05" id="M9" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 64.662498 12.05" width="64.662498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="24.655916" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="35.996136" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">8</tspan>
</text>
</g>
</g>
</svg></span></td><td align="center"><span style="width: 72.474998px;"><svg height="12.2375" id="M10" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">7</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">7</tspan>
<tspan style="font-size: 12.50px; " x="18.754499" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="21.880251" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="30.907415" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="48.499138" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">5</tspan>
</text>
</g>
</g>
</svg></span></td></tr><tr><td align="left">Friability (%)</td><td align="center"><span style="width: 72.474998px;"><svg height="12.05" id="M11" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.05" width="72.474998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="24.655916" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="35.996136" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">4</tspan>
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</g>
</g>
</svg></span></td><td align="center"><span style="width: 72.474998px;"><svg height="12.2375" id="M12" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="24.655916" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="35.996136" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">5</tspan>
</text>
</g>
</g>
</svg></span></td></tr><tr><td align="left">Desegregation (s)</td><td align="center"><span style="width: 41.224998px;"><svg height="12.05" id="M13" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 41.224998 12.05" width="41.224998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="15.278666" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="26.618887" y="0">4</tspan>
</text>
</g>
</g>
</svg></span></td><td align="center"><span style="width: 41.224998px;"><svg height="12.05" id="M14" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 41.224998 12.05" width="41.224998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="15.278666" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="26.618887" y="0">2</tspan>
</text>
</g>
</g>
</svg></span></td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Tablets characterization and Pharmacopoeia controls.

Journal of Drug Delivery

tab2

Table 2

Table 2: A New Application of Lipid Nanoemulsions as Coating Agent, Providing Zero-Order Hydrophilic Drug Release from Tablets 