In Vitro Investigation of a Terbinafine Impregnated Subcutaneous Implant for Veterinary Use

Table 1

Mean (SD) amount of terbinafine (𝜇g) released from 0.5 mg implants in isotonic saline at two different temperatures, 4^°C and 37^°C. A 𝑡-test or Mann-Whitney/Wilcoxon 2-sample test was performed to determine if means differed between the two temperatures at the different time points. A P of <0.05 (*) denotes a significant difference.

Weeks after initial placement into saline	4^°C		37^°C		𝑃 value
	Mean	SD	Mean	SD
1	3.4	0.6	4.8	0.2	<0.01^*
2	20.3	12.7	5.2	4.6	0.04^*
3	19.9	21.2	−8.0	6.1	0.02^*
4	3.7	15.1	20.3	21.3	0.19
5	5.7	1.9	−3.2	23.0	0.75
6	−2.3	10.6	12.6	10.8	0.06
7	−20.2	55.6	−1.6	21.0	0.70
8	6.0	54.3	14.2	7.5	0.17
9	10.9	14.7	14.4	12.4	0.70
10	−0.4	8.9	4.2	33.2	0.60
11	−2.1	6.0	5.5	6.3	0.09
12	−1.4	8.6	1.0	4.8	0.60
13	5.7	6.4	6.3	4.7	0.88
14	3.6	5.5	−4.7	9.3	0.12
15	−4.5	4.9	−3.7	8.5	0.86
16	4.7	8.4	−0.4	11.2	0.44
17	−3.2	3.7	11.0	5.5	<0.01^*
18	−0.8	1.8	2.9	5.6	0.19
19	12.4	3.3	13.4	6.9	0.78
20	−0.2	11.6	0.4	2.3	0.91
21	−0.1	8.8	8.8	6.5	0.10
22	1.5	6.6	15.0	27.7	0.32
24	3.6	4.2	−6.0	21.4	0.35
25	−12.7	7.5	−9.5	5.0	0.45
26	0.6	7.1	10.2	4.1	0.03^*
27	−6.3	2.5	−2.6	3.3	0.08
28	−1.9	4.9	6.7	6.4	0.04^*