Composite Polylactic-Methacrylic Acid Copolymer Nanoparticles for the Delivery of Methotrexate

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Variables</td><td align="center">Limits</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Quantity of PLA</td><td align="center">2–6 mg</td></tr><tr><td align="left">Quantity of MAA</td><td align="center">5–30 mg</td></tr><tr><td align="left">Ratio (<svg height="10.9375" id="M12" style="vertical-align:-0.20064pt" version="1.1" viewbox="0 0 38.349998 10.9375" width="38.349998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.9375)">
<g transform="translate(72,-63.25)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑊</tspan>
<tspan style="font-size: 12.50px; " x="11.452748" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="17.704248" y="0">/</tspan>
<tspan style="font-size: 12.50px; " x="21.180082" y="0">𝑂</tspan>
</text>
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</svg>)</td><td align="center">1: 4–1: 6</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Formulation constraints employed for response optimization.

Journal of Drug Delivery

tab4

Table 4

Table 4: Composite Polylactic-Methacrylic Acid Copolymer Nanoparticles for the Delivery of Methotrexate 