Research Article
Composite Polylactic-Methacrylic Acid Copolymer Nanoparticles for the Delivery of Methotrexate
Table 5
Computed molecular attributes of the complexes involving PLA, MAA, and MTX.
| | Structure | Molecular attributes | | Surface area (grid) | Volume (cm3) | Surface-to-volume ratio | Refractivity | ΔRefa |
| | PLA | 922.53 | 1828.26 | 0.5046 | 156.96 | — | | MAA | 987.05 | 1954.76 | 0.5049 | 195.59 | — | | MTX | 726.43 | 1255.51 | 0.5786 | 114.60 | — | | PLA-MTX | 1373.47 | 2855.10 | 0.4811 | 270.67 | −0.89 | | MAA-MTX | 1315.76 | 2874.97 | 0.4577 | 307.21 | −2.98 |
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Ref = Ref(Host)− Ref(Guest).
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