Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb

Table 9

Clinical trials performed with Novasorb.

Year	Phase type	Product	Objectives	Indication	No. of patients
2003	Phase I	Vehicle no.1	Tolerance and safety	None	16
2004	Phase II		Tolerance and safety,; Exploratory efficacy	Dry eye	50
2005	Phase II	Cationorm; (Vehicle no.2)	Efficacy, tolerance, and safety	Dry eye	79
2010	Phase II		Efficacy, tolerance, and safety	Dry eye	71
2005	Phase IIa	Cyclokat	Tolerance and safety; Exploratory efficacy	Dry eye disease	48
2008	Phase IIb		Exploratory efficacy, tolerance, and safety	Dry eye disease	132
2009	Phase III “Siccanove”		Efficacy, tolerance, and safety	Dry eye disease	496
2011	Phase III “Sansika”		Efficacy, tolerance, and safety	Dry eye disease	252
2006	Phase IIb/III	Vekacia	Efficacy, tolerance, and safety	Active VKC	118
2009	Phase IIb		Efficacy, tolerance, and safety	Nonactive VKC	34
2011	Phase II	Catioprost	Exploratory efficacy, open-label study	Glaucoma	NA
2011	Phase IIb		Exploratory efficacy, tolerance, and safety	Glaucoma	100

VKC: Vernal keratoconjunctivitis.