Research Article
Development and Evaluation of a Novel Pellet-Based Tablet System for Potential Colon Delivery of Budesonide
Table 2
Formulation details of pellets and multiunit tablets.
| Formulation
code |
Dosage form | Pellet composition | Inert tabletting excipient (w/w% of tablet weight) | | | | Barrier coat Xanthan gum (%TWG)* | Inner coat L30D/NE30D (ratio) (%TWG) | Outer coat FS 30D (%TWG) | |
| | F1 | Coated pellets | — | (0 : 10) (10) | — | — | | F2 | Coated pellets | — | (0 : 10) (20) | — | — | | F3 | Coated pellets | — | (0 : 10) (30) | — | — | | F4 | Coated pellets | — | (1 : 9) (30) | — | — | | F5 | Coated pellets | — | (2 : 8) (30) | — | — | | F6 | Coated pellets | — | (3 : 7) (30) | — | — | | F7 | Coated pellets | 2.5 | (3 : 7) (30) | — | — | | F8 | Coated pellets | 5 | (3 : 7) (30) | — | — | | F9 | Coated pellets | 10 | (3 : 7) (30) | — | — | | F10 | Coated pellets | 10 | (3 : 7) (30) | 12 | — | | F11 | Coated pellets | 10 | (3 : 7) (30) | 25 | — | | F12 | Multiple unit tablet | 10 | (3 : 7) (30) | 25 | 30 (Pearlitol) | | F13 | Multiple unit tablet | 10 | (3 : 7) (30) | 25 | 50 (Pearlitol) | | F14 | Multiple unit tablet | 10 | (3 : 7) (30) | 25 | 30 (Cellactose) | | F15 | Multiple unit tablet | 10 | (3 : 7) (30) | 25 | 40 (Cellactose) |
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