Journal of Drug Delivery / 2012 / Article / Tab 2

Research Article

The Safety of EXPAREL ® (Bupivacaine Liposome Injectable Suspension) Administered by Peripheral Nerve Block in Rabbits and Dogs

Table 2

Injection site findings (Day 3 and Day 15) in dogs (combined sexes).

Day 3ObservationsSeverity gradeSalineEXP 9 mg/kgEXP 18 mg/kgEXP 25 mg/kgBsol 9 mg/kg

Brachial plexus, distalDegeneration/regeneration myofibersmild00001
Hemorrhage, adipose tissuemild00010
minimal03131
Inflammation, granulomatous, adipose tissueminimal00110
Inflammation, subacuteminimal00001

Brachial plexus, middleDegeneration/regeneration myofibermild00001
Hemorrhageminimal04010
mild01210
moderate00000
Inflammation, granulomatousminimal01000

Brachial plexus, proximalHemorrhagemild01210
Inflammation, adipose tissue, subacutemild00010

Day 15

Brachial plexus, distalDegeneration/regeneration myofibersmild00001
Hemorrhageminimal20102
Brachial plexus, middleCystminimal00100
Fibrosisminimal00000
Hemorrhageminimal11120
mild00001
Inflammation, granulomatousminimal00120

Brachial plexus, proximalDegeneration/regeneraton myofibersminimal00101
Hemorrhageminimal01101
Inflammation, granulomatousminimal00110
mild00100

Refer to Table 1 footnote.

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