The Safety of EXPAREL ® (Bupivacaine Liposome Injectable Suspension) Administered by Peripheral Nerve Block in Rabbits and Dogs

Table 2

Injection site findings (Day 3 and Day 15) in dogs (combined sexes).

Day 3	Observations	Severity grade	Saline	EXP 9 mg/kg	EXP 18 mg/kg	EXP 25 mg/kg	Bsol 9 mg/kg
Brachial plexus, distal	Degeneration/regeneration myofibers	mild	0	0	0	0	1
	Hemorrhage, adipose tissue	mild	0	0	0	1	0
		minimal	0	3	1	3	1
	Inflammation, granulomatous, adipose tissue	minimal	0	0	1	1	0
	Inflammation, subacute	minimal	0	0	0	0	1
Brachial plexus, middle	Degeneration/regeneration myofiber	mild	0	0	0	0	1
	Hemorrhage	minimal	0	4	0	1	0
		mild	0	1	2	1	0
		moderate	0	0	0	0	0
	Inflammation, granulomatous	minimal	0	1	0	0	0
Brachial plexus, proximal	Hemorrhage	mild	0	1	2	1	0
	Inflammation, adipose tissue, subacute	mild	0	0	0	1	0
Day 15
Brachial plexus, distal	Degeneration/regeneration myofibers	mild	0	0	0	0	1
	Hemorrhage	minimal	2	0	1	0	2
Brachial plexus, middle	Cyst	minimal	0	0	1	0	0
	Fibrosis	minimal	0	0	0	0	0
	Hemorrhage	minimal	1	1	1	2	0
		mild	0	0	0	0	1
	Inflammation, granulomatous	minimal	0	0	1	2	0
Brachial plexus, proximal	Degeneration/regeneraton myofibers	minimal	0	0	1	0	1
	Hemorrhage	minimal	0	1	1	0	1
	Inflammation, granulomatous	minimal	0	0	1	1	0
		mild	0	0	1	0	0

Refer to Table 1 footnote.