Formulation Strategies, Characterization, and In Vitro Evaluation of Lecithin-Based Nanoparticles for siRNA Delivery
Figure 5
Transmission electron micrographs of the lecithin-based nanoparticles. Lecithin-based dispersions containing 25 mM phosphatidylcholine, alone in pH 5.0 (a) and pH 7.0 (c) buffers, are shown. The same dispersions were then loaded with siRNA at N/P = 8000 and incubated, and the siRNA-loaded nanoparticles were observed (b and d, resp.).
