Formulation Strategies, Characterization, and In Vitro Evaluation of Lecithin-Based Nanoparticles for siRNA Delivery
Figure 7
Fluo-siRNA uptake by MCF-7 cells transfected with lecithin dispersions in pH 5.0 and pH 7.0 buffers. Control dsRNA:Lipofectamine (a), dsRNA alone (b), dsRNA:lecithin 25 mM pH 5.0 (c), and dsRNA:lecithin 25 mM pH 7.0 (d) at N/P 8000 were incubated with the MCF-7 cells for 18 h. Afterwards, cells were washed and fixed, and fluorescent signal was visualized by microscopy.
