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Journal of Drug Delivery
Volume 2013 (2013), Article ID 107573, 7 pages
http://dx.doi.org/10.1155/2013/107573
Review Article

Convection-Enhanced Delivery for Targeted Delivery of Antiglioma Agents: The Translational Experience

1Gabriele Bartoli Brain Tumor Laboratory, Departments of Neurosurgery, Columbia University Medical Center, 1130 St. Nicholas Avenue Room 1001, New York, NY 10032, USA
2Pathology and Cell Biology, Columbia University Medical Center, 1130 St. Nicholas Avenue Room 1001, New York, NY 10032, USA
3Department of Neurological Surgery, Neurological Institute of New York, 710 West 168th Street, New York, NY 10032, USA

Received 23 November 2012; Accepted 10 December 2012

Academic Editor: Andreas G. Tzakos

Copyright © 2013 Jonathan Yun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recent improvements in the understanding of glioblastoma (GBM) have allowed for increased ability to develop specific, targeted therapies. In parallel, however, there is a need for effective methods of delivery to circumvent the therapeutic obstacles presented by the blood-brain barrier and systemic side effects. The ideal delivery system should allow for adequate targeting of the tumor while minimizing systemic exposure, applicability across a wide range of potential therapies, and have existing safe and efficacious systems that allow for widespread application. Though many alternatives to systemic delivery have been developed, this paper will focus on our experience with convection-enhanced delivery (CED) and our focus on translating this technology from pre-clinical studies to the treatment of human GBM.