Development of Dorzolamide Loaded 6-O-Carboxymethyl Chitosan Nanoparticles for Open Angle Glaucoma

Table 6

Effect of drug loading on zeta potential and EE of OCM-CSNs.

OCM-CS : CaCl2 weight ratio	Zeta potential (mV)		EE of OCM-CSNs
	DRZ loading (50%)	Blank OCM-CSNs
6 : 1	−28.57±0.513	−32.57±0.571	18.13±0.47
5 : 1	−24.57±1.858	−27.19±0.337	13.71±0.53
4 : 1	−18.03±0.404	−24.87±0.259	9.37±0.36

Values are expressed as mean ± standard deviation, 𝑛=3.
OCM-CS: 6-𝑂-carboxymethyl chitosan; CaCl₂: calcium chloride; NPs: nanoparticles; EE: entrapment efficiency; OCM-CSNs: 6-𝑂-carboxymethyl chitosan nanoparticles.