Development of Dorzolamide Loaded 6-O-Carboxymethyl Chitosan Nanoparticles for Open Angle Glaucoma

Table 7

Effect of drug loading on zeta potential and EE of CSNs.

CS : TPP weight ratio	Zeta potential (mV)		EE of CSNs
	DRZ loading (50%)	Blank CSNs
6 : 1	+32.47±0.723	+28.58±0.421	20.08±0.87
5 : 1	+25.33±0.404	+23.79±0.234	16.29±0.61
4 : 1	+22.13±0.351	+21.58±0.347	10.51±0.57

Values are expressed as mean ± standard deviation, 𝑛=3.
CS: chitosan; TPP: tripolyphosphate; EE: entrapment efficiency; NPs: nanoparticles; CSNs: chitosan nanoparticles.