Design Optimization and In Vitro-In Vivo Evaluation of Orally Dissolving Strips of Clobazam

Table 2

Factorial design with disintegration time, tensile strength, and % drug release obtained.

Run	Factor	Factor	DT (sec)	TS (N/cm^2)	% drug release
1	−1	−1			79.1
2	0	−1			85
3	+1	−1			89
4	−1	0			79.4
5	0	0			83.1
6	+1	0			96.6
7	−1	+1			68.9
8	0	+1			70
9	+1	+1			82.1

DT = disintegration time.
TS = tensile strength.