Design Optimization and In Vitro-In Vivo Evaluation of Orally Dissolving Strips of Clobazam

Table 3

Composition of different orally dissolving strips containing clobazam.

Ingredients	Formulation batches
	F1	F2	F3	F4	F5	F6	F7	F8	F9
Clobazam (mg)	5	5	5	5	5	5	5	5	5
PVA (mg)	50	50	50	100	100	100	200	200	200
PEG 400 (mg)	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3
SSG (mg)	2	4	6	2	4	6	2	4	6
D-Mannitol (mg)	25	25	25	25	25	25	25	25	25
Water (mL)	10	10	10	10	10	10	10	10	10

The concentration of the drug was 5 mg/4 cm² of the film.