Interaction Study of an Amorphous Solid Dispersion of Cyclosporin A in Poly-Alpha-Cyclodextrin with Model Membranes by 1H-, 2H-, 31P-NMR and Electron Spin Resonance
Figure 2
(a) 1H-NMR spectra (297 K, D2O) of pure 2 mM POLYA (bottom trace) and the 1/1 preparation (top trace); dashed lines represent several of the chemical shift variations observed. (b) Job plots built from the different proton chemical shift variations: 5.29 ppm (d) H1 —; 3.65() H2 ▲; 4,05() H3 ; 3.95(), H4 ; 4.27(), H5 ●; 3.00(), (H6-6′) ■.
