Research Article
Preparation and the Biopharmaceutical Evaluation for the Metered Dose Transdermal Spray of Dexketoprofen
Table 10
Pharmacokinetic parameters of dexketoprofen after IV, oral, and transdermal administration in rats (mean ± SD;
).
| | Parameters | IV | Oral | DE MDTS |
| | AUC (ng·mL−1·h) | 494.442 ± 20.788 | 296.662 ± 44.321 | 185.137 ± 67.792 | | MRT (h) | 9.311 ± 1.113 | 8.758 ± 0.682 | 13.459 ± 0.684 | | (h) | 5.555 ± 2.018 | 3.778 ± 1.67 | 7.688 ± 2.546 | | (h) | 0.083 ± 0 | 1.5 ± 1.683 | 6.5 ± 1 | | (ng/mL) | 80.43 ± 8.67 | 23.875 ± 4.632 | 11.231 ± 4.676 |
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