Preparation and the Biopharmaceutical Evaluation for the Metered Dose Transdermal Spray of Dexketoprofen

Table 4

Skin irritation score scale.

Grading	Description of irritant response
0	No reaction
+	Weakly positive reaction (usually characterized by mild erythema across most of the treatment site)
+ +	Moderate positive reaction (usually distinct erythema possibly spreading beyond the treatment site)
+ + +	Strongly positive reaction (strong, often spreading erythema with edema)