Formulation and Evaluation of Optimized Oxybenzone Microsponge Gel for Topical Delivery

Table 1

Factorial design and characterization of experimental formulations.

Formulations; (EC, DCM); (mg, mL)	% EE ± SD	% DC ± SD	% production yield	Particle size (0.9); m ± SD	% DR ± SD
M1 (100, 3)	92.3 ± 0.12	67.12 ± 0.42	50.14 ± 0.28	496 ± 0.12	20.08 ± 0.02
M2 (100, 5)	93.7 ± 0.22	70.00 ± 0.56	59.76 ± 0.10	619 ± 0.02	21.08 ± 0.82
M3 (100, 7)	98.6 ± 0.14	73.54 ± 0.82	73.54 ± 0.16	146 ± 0.32	22.28 ± 0.72
M4 (200, 3)	90.1 ± 0.21	44.26 ± 0.42	44.10 ± 0.14	347 ± 0.42	12.19 ± 0.42
M5 (200, 5)	96.3 ± 0.56	67.54 ± 0.32	67.76 ± 0.72	224 ± 0.52	12.88 ± 0.32
M6 (200, 7)	98.5 ± 0.72	54.28 ± 0.22	55.22 ± 0.32	105 ± 0.62	13.74 ± 0.42
M7 (300, 3)	95.3 ± 0.92	65.33 ± 0.29	65.11 ± 0.42	272 ± 0.02	12.23 ± 0.02
M8 (300, 5)	96.7 ± 0.62	42.02 ± 0.12	42.78 ± 0.62	119 ± 0.28	12.94 ± 0.11
M9 (300, 7)	96.9 ± 0.52	77.87 ± 0.92	77.56 ± 0.20	072 ± 0.77	13.76 ± 0.10