Reassessing the Role of Intra-Arterial Drug Delivery for Glioblastoma Multiforme Treatment

Figure 3

Hypoperfusion-assisted intra-arterial drug delivery. Transient cerebral hypoperfusion (TCH) significantly facilitates the delivery of cationic liposomes to the brain. Multispectral images (MSI) show that cationic liposomal uptake is significantly improved by utilizing intra-arterial delivery with TCH (right panel). Corresponding concentration-time curves obtained by diffuse reflectance spectroscopy quantitatively corroborate these optical phenomena (left panel).