Reassessing the Role of Intra-Arterial Drug Delivery for Glioblastoma Multiforme Treatment

Table 3

Optical methods employed to study IA drug pharmacokinetics.

Method	Depth	Advantage	Disadvantage
Diffuse reflectance spectroscopy	1-2 mm	(i) Insensitive to scattering changes; (ii) Low cost; (iii) High spectral resolution	(i) Recovery of relative absorption; (ii) Low spatial resolution
Diffuse optical tomography	up to ~4 cm	3D reconstruction of absolute optical pharmacokinetics (OP)	(i) Expensive; (ii) Bulky; (iii) Low spectral resolution
Frequency domain photon migration	up to ~4 cm	Recovery of absolute OP	(i) Low spectral resolution; (ii) Expensive; (iii) Low spatial resolution; (iv) Not suitable for small geometries
Diffuse optical spectroscopic imaging	up to ~4 cm	(i) 3D reconstruction of absolute OP; (ii) High spectral resolution	(i) Expensive; (ii) Not suitable for small geometries
Spatial frequency domain imaging	up to ~1 cm	(i) Noncontact; (ii) High spatial resolution; (iii) Depth sensitivity	(i) Long acquisition times; (ii) Expensive (commercial)
Multispectral imaging	up to ~1 cm	(i) Low cost; (ii) High spatiotemporal acquisition rate	(i) Relative absorption values; (ii) Susceptible to scattering effects; (iii) No depth resolution