High-Resolution Imaging of Polyethylene Glycol Coated Dendrimers via Combined Atomic Force and Scanning Tunneling Microscopy

Figure 1

AFM tapping mode imaging of G4-PAMAM-50PEG₁₀₀₀ dendrimers. 300 × 300 nm² topographic images of G4-PAMAM-50PEG₁₀₀₀ acquired at a damping set point of 42% (a) and 23% (b). 300 × 300 nm² AFM topographic images of G4-PAMAM-NH₂ at damping set points of 42% (c), and 23% (d). Cursor profile 1 is a representative G4-PAMAM-50PEG₁₀₀₀ and G4-PAMAM-NH₂ dendrimer imaged with 42% dampening as indicated in (a) (red) and (c) (blue). Cursor profile 2 is a representative G4-PAMAM-50PEG₁₀₀₀ and G4-PAMAM-NH₂ dendrimer imaged with 23% dampening as indicated in (b) (red) and (d) (blue).