Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate, Cetirizine Hydrochloride in Combined Pharmaceutical Dosage Form: A New Era in Novel Drug Delivery for Pediatrics and Geriatrics

Table 6

Evaluation parameters for the optimization of PVP K-30 or MCC with optimized concentration of SSG.

Formula number	Evaluation parameters
	Weight variation (IP)	Friability (%)	Hardness (Kg/cm^2) ± S.D	Disintegration time (Sec) ± S.D
F1	Passed	0.1	2.2 ± 0.28	60 ± 1.78
F2	Passed	0.2	1.8 ± 0.28	47 ± 2.45
F3	Passed	0.5	2.0 ± 0.00	69 ± 2.89
F4	Passed	0.3	3.2 ± 0.76	83 ± 2.40
F5	Passed	0.3	1.6 ± 0.50	90 ± 5.16
F6	Passed	0.8	2.5 ± 0.50	120 ± 5.77
F7	Passed	0.8	2.0 ± 0.00	145 ± 5.43
F8	Passed	0.1	1.5 ± 0.50	38 ± 4.34
F9	Passed	0.1	1.5 ± 0.28	47 ± 2.34
F10	Passed	0.2	1.5 ± 0.28	62 ± 3.10
F11	Passed	0.1	1.8 ± 0.28	75 ± 1.32
F12	Passed	0.1	1.5 ± 0.28	82 ± 2.08
F13	Passed	0.1	1.8 ± 0.28	94 ± 3.67
F14	Passed	0.1	1.8 ± 0.28	110 ± 2.78

Average of three determinations.
Average of six determinations.